ctcRbase

Entry Detail

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General Information

Database ID: BRCA07562 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MDM4 Full Name: MDM4, p53 regulator Category: mRNA Synonyms: HDMX|MDMX|MRP1 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 204516379 End Site(bp): 204558120 Gene Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000198625 HGNC ID: HGNC:6974 Entrez Gene: 4194

Expression Profile of MDM4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p NO YES YES hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-122-5p YES YES NO hsa-miR-128-3p NO YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-135a-5p NO YES YES hsa-miR-135b-5p NO YES YES hsa-miR-137 YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-185-5p NO YES YES hsa-miR-191-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-205-5p NO YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-221-3p NO YES YES hsa-miR-222-3p NO YES YES hsa-miR-299-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-33a-5p NO YES YES hsa-miR-34a-5p NO YES YES hsa-miR-34c-5p NO YES YES hsa-miR-361-5p NO YES YES hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-449a NO YES YES hsa-miR-449b-5p NO YES YES hsa-miR-454-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-93-5p YES YES NO Display: