ctcRbase

Entry Detail

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General Information

Database ID: BRCA07614 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: TNFSF10 Full Name: TNF superfamily member 10 Category: mRNA Synonyms: APO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 172505508 End Site(bp): 172523507 Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000121858 HGNC ID: HGNC:11925 Entrez Gene: 8743

Expression Profile of TNFSF10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-122-5p YES YES NO hsa-miR-130a-3p NO YES YES hsa-miR-130b-3p NO YES YES hsa-miR-137 YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-301a-3p NO YES YES hsa-miR-301b-3p NO YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-454-3p NO YES YES hsa-miR-490-3p YES YES NO hsa-miR-98-5p YES YES NO Display: