ctcRbase

Entry Detail

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General Information

Database ID: BRCA08170 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MAP3K8 Full Name: mitogen-activated protein kinase kinase kinase 8 Category: mRNA Synonyms: AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 30433937 End Site(bp): 30461833 Gene Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] External Links: Ensembl ID: ENSG00000107968 HGNC ID: HGNC:6860 Entrez Gene: 1326

Expression Profile of MAP3K8 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-137 YES YES NO hsa-miR-144-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-299-3p YES YES YES hsa-miR-299-5p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-590-5p YES YES YES hsa-miR-93-5p YES YES YES hsa-miR-9-5p YES YES NO Display: