ctcRbase

Entry Detail

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General Information

Database ID: BRCA08283 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: PRKAR2B Full Name: protein kinase cAMP-dependent type II regulatory subunit beta Category: mRNA Synonyms: PRKAR2|RII-BETA Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 107044649 End Site(bp): 107161811 Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000005249 HGNC ID: HGNC:9392 Entrez Gene: 5577

Expression Profile of PRKAR2B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-107 YES YES NO hsa-miR-137 YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-361-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES NO Display: