ctcRbase

Entry Detail

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General Information

Database ID: BRCA08904 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: RASSF1 Full Name: Ras association domain family member 1 Category: mRNA Synonyms: 123F2|NORE2A|RASSF1A|RDA32|REH3P21 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 50329782 End Site(bp): 50340980 Gene Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000068028 HGNC ID: HGNC:9882 Entrez Gene: 11186

Expression Profile of RASSF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-326 YES YES YES hsa-miR-328-3p YES YES NO hsa-miR-330-5p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-342-3p YES NO YES hsa-miR-346 YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-96-5p YES YES NO Display: