ctcRbase

Entry Detail

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General Information

Database ID: BRCA09147 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PPP1R12A Full Name: protein phosphatase 1 regulatory subunit 12A Category: mRNA Synonyms: M130|MBS|MYPT1 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 79773563 End Site(bp): 79935460 Gene Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] External Links: Ensembl ID: ENSG00000058272 HGNC ID: HGNC:7618 Entrez Gene: 4659

Expression Profile of PPP1R12A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES NO YES hsa-miR-129-5p YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-140-5p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-182-5p YES NO YES hsa-miR-186-5p NO YES YES hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-20a-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-300 YES NO NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-376c-3p YES YES NO hsa-miR-377-3p NO YES YES hsa-miR-381-3p YES NO NO hsa-miR-410-3p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-455-5p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES NO YES Display: