ctcRbase

Entry Detail

---



General Information

Database ID: BRCA09309 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: IPO5 Full Name: importin 5 Category: mRNA Synonyms: IMB3|KPNB3|Pse1|RANBP5|imp5 Chromosome: chr13 Strand: + Coordinate: Start Site(bp): 97953658 End Site(bp): 98024297 Gene Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000065150 HGNC ID: HGNC:6402 Entrez Gene: 3843

Expression Profile of IPO5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1224-5p YES NO YES hsa-miR-136-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-147a YES NO NO hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-150-5p YES YES NO hsa-miR-152-3p YES NO YES hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-204-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-210-3p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-25-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-329-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-362-3p YES NO YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-374a-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-421 YES YES YES hsa-miR-425-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-519d-3p YES YES NO hsa-miR-543 YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES YES NO Display: