ctcRbase

Entry Detail

---



General Information

Database ID: BRCA09453 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SECISBP2 Full Name: SECIS binding protein 2 Category: mRNA Synonyms: SBP2 Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 89318506 End Site(bp): 89359662 Gene Summary: The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000187742 HGNC ID: HGNC:30972 Entrez Gene: 79048

Expression Profile of SECISBP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-653-5p YES YES NO Display: