ctcRbase

Entry Detail

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General Information

Database ID: BRCA09979 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: KPNB1 Full Name: karyopherin subunit beta 1 Category: mRNA Synonyms: IMB1|IPO1|IPOB|Impnb|NTF97 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 47649476 End Site(bp): 47685505 Gene Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] External Links: Ensembl ID: ENSG00000108424 HGNC ID: HGNC:6400 Entrez Gene: 3837

Expression Profile of KPNB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-136-5p YES YES NO hsa-miR-140-3p YES NO YES hsa-miR-145-5p YES NO YES hsa-miR-147a YES NO NO hsa-miR-154-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-218-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-28-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-342-3p YES YES NO hsa-miR-346 YES YES NO hsa-miR-361-5p YES YES YES hsa-miR-362-3p YES NO NO hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-483-3p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-548o-3p YES NO NO hsa-miR-599 YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES YES Display: