ctcRbase

Entry Detail

---



General Information

Database ID: BRCA10363 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: RUNX1T1 Full Name: RUNX1 translocation partner 1 Category: mRNA Synonyms: AML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 91954967 End Site(bp): 92103286 Gene Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] External Links: Ensembl ID: ENSG00000079102 HGNC ID: HGNC:1535 Entrez Gene: 862

Expression Profile of RUNX1T1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES YES YES hsa-miR-328-3p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO Display: