ctcRbase

Entry Detail

---



General Information

Database ID: BRCA10526 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PPP1R12B Full Name: protein phosphatase 1 regulatory subunit 12B Category: mRNA Synonyms: MYPT2|PP1bp55 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 202348699 End Site(bp): 202592706 Gene Summary: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000077157 HGNC ID: HGNC:7619 Entrez Gene: 4660

Expression Profile of PPP1R12B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-1224-5p YES NO NO hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-625-5p YES NO NO hsa-miR-98-5p YES NO YES Display: