ctcRbase

Entry Detail

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General Information

Database ID: BRCA10761 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: GADD45B Full Name: growth arrest and DNA damage inducible beta Category: mRNA Synonyms: GADD45BETA|MYD118 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 2476122 End Site(bp): 2478259 Gene Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000099860 HGNC ID: HGNC:4096 Entrez Gene: 4616

Expression Profile of GADD45B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-140-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-411-5p YES YES NO hsa-miR-454-3p YES YES YES Display: