ctcRbase

Entry Detail

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General Information

Database ID: BRCA10839 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PRKCH Full Name: protein kinase C eta Category: mRNA Synonyms: PKC-L|PKCL|PRKCL|nPKC-eta Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 61187559 End Site(bp): 61550976 Gene Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000027075 HGNC ID: HGNC:9403 Entrez Gene: 5583

Expression Profile of PRKCH Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-422a YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-874-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES NO Display: