ctcRbase

Entry Detail

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General Information

Database ID: BRCA10963 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PDGFRA Full Name: platelet derived growth factor receptor alpha Category: mRNA Synonyms: CD140A|PDGFR-2|PDGFR2 Chromosome: chr4 Strand: + Coordinate: Start Site(bp): 54229097 End Site(bp): 54298247 Gene Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000134853 HGNC ID: HGNC:8803 Entrez Gene: 5156

Expression Profile of PDGFRA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-140-5p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-143-3p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-223-3p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-455-5p YES YES YES hsa-miR-491-5p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-599 YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-93-5p YES YES YES hsa-miR-96-5p YES YES YES Display: