ctcRbase

Entry Detail

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General Information

Database ID: BRCA11845 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PRKAA2 Full Name: protein kinase AMP-activated catalytic subunit alpha 2 Category: mRNA Synonyms: AMPK|AMPK2|AMPKa2|PRKAA Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 56645322 End Site(bp): 56715335 Gene Summary: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000162409 HGNC ID: HGNC:9377 Entrez Gene: 5563

Expression Profile of PRKAA2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-10a-5p YES NO YES hsa-miR-10b-5p YES NO YES hsa-miR-1271-5p YES NO YES hsa-miR-1294 YES NO NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-151a-3p YES NO YES hsa-miR-154-5p YES NO YES hsa-miR-182-5p YES NO YES hsa-miR-186-5p YES YES YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-219a-5p YES NO YES hsa-miR-25-3p YES NO YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-31-5p YES YES YES hsa-miR-32-5p YES NO YES hsa-miR-335-5p YES YES YES hsa-miR-363-3p YES NO YES hsa-miR-367-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-421 YES NO YES hsa-miR-454-3p YES YES NO hsa-miR-499a-5p YES NO YES hsa-miR-543 YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-668-3p YES NO YES hsa-miR-92a-3p YES NO YES hsa-miR-92b-3p YES NO YES hsa-miR-96-5p YES NO YES hsa-miR-98-5p YES NO YES Display: