ctcRbase

Entry Detail

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General Information

Database ID: BRCA12381 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: BBC3 Full Name: BCL2 binding component 3 Category: mRNA Synonyms: JFY-1|JFY1|PUMA Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 47220822 End Site(bp): 47232766 Gene Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] External Links: Ensembl ID: ENSG00000105327 HGNC ID: HGNC:17868 Entrez Gene: 27113

Expression Profile of BBC3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-1298-5p YES NO YES hsa-miR-139-5p YES NO YES hsa-miR-143-3p YES NO YES hsa-miR-144-3p YES YES YES hsa-miR-149-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-296-5p YES NO YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-300 YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-494-3p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-665 YES NO YES Display: