ctcRbase

Entry Detail

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General Information

Database ID: BRCA12572 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SUN2 Full Name: Sad1 and UNC84 domain containing 2 Category: mRNA Synonyms: UNC84B Chromosome: chr22 Strand: - Coordinate: Start Site(bp): 38734725 End Site(bp): 38794143 Gene Summary: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] External Links: Ensembl ID: ENSG00000100242 HGNC ID: HGNC:14210 Entrez Gene: 25777

Expression Profile of SUN2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-542-3p YES YES YES hsa-miR-758-3p YES YES YES hsa-miR-873-5p YES YES NO Display: