ctcRbase

Entry Detail

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General Information

Database ID: BRCA12976 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CLK4 Full Name: CDC like kinase 4 Category: mRNA Synonyms: - Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 178602664 End Site(bp): 178630615 Gene Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000113240 HGNC ID: HGNC:13659 Entrez Gene: 57396

Expression Profile of CLK4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-186-5p YES YES NO hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO Display: