ctcRbase

Entry Detail

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General Information

Database ID: BRCA13356 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PPP1R15B Full Name: protein phosphatase 1 regulatory subunit 15B Category: mRNA Synonyms: CREP|MSSGM2 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 204403387 End Site(bp): 204411791 Gene Summary: This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016] External Links: Ensembl ID: ENSG00000158615 HGNC ID: HGNC:14951 Entrez Gene: 84919

Expression Profile of PPP1R15B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-141-3p YES YES YES hsa-miR-142-3p YES NO YES hsa-miR-146b-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES YES hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200a-3p YES YES YES hsa-miR-205-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-542-3p YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-760 YES NO YES hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES YES YES Display: