ctcRbase

Entry Detail

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General Information

Database ID: BRCA13655 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: INSR Full Name: insulin receptor Category: mRNA Synonyms: CD220|HHF5 Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 7112255 End Site(bp): 7294034 Gene Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000171105 HGNC ID: HGNC:6091 Entrez Gene: 3643

Expression Profile of INSR Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1224-5p YES NO YES hsa-miR-128-3p YES NO YES hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-136-5p YES YES NO hsa-miR-151a-3p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-205-5p YES NO YES hsa-miR-208a-3p YES NO YES hsa-miR-208b-3p YES NO YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-302e YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-342-3p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-372-3p YES YES NO hsa-miR-375 YES NO YES hsa-miR-379-5p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES NO YES hsa-miR-503-5p YES NO NO hsa-miR-505-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-760 YES NO YES hsa-miR-93-5p YES YES NO hsa-miR-98-5p YES YES YES Display: