ctcRbase

Entry Detail

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General Information

Database ID: BRCA14045 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CASP2 Full Name: caspase 2 Category: mRNA Synonyms: CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 143288215 End Site(bp): 143307696 Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] External Links: Ensembl ID: ENSG00000106144 HGNC ID: HGNC:1503 Entrez Gene: 835

Expression Profile of CASP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-1271-5p YES YES YES hsa-miR-143-3p YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-28-5p YES YES YES hsa-miR-299-3p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-342-3p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-423-5p YES NO YES hsa-miR-429 YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-551a YES YES NO hsa-miR-551b-3p YES YES NO hsa-miR-708-5p YES YES YES hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES YES Display: