ctcRbase

Entry Detail

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General Information

Database ID: BRCA14658 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: KLF4 Full Name: Kruppel like factor 4 Category: mRNA Synonyms: EZF|GKLF Chromosome: chr9 Strand: - Coordinate: Start Site(bp): 107484852 End Site(bp): 107490482 Gene Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000136826 HGNC ID: HGNC:6348 Entrez Gene: 9314

Expression Profile of KLF4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-128-3p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-137 YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-140-3p YES NO YES hsa-miR-145-5p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-206 YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-346 YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES NO YES hsa-miR-375 YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-7-5p YES YES YES hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES NO Display: