ctcRbase

Entry Detail

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General Information

Database ID: BRCA14782 Cancer Type: breast cancer Dataset: GSE86978 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PTGS1 Full Name: prostaglandin-endoperoxide synthase 1 Category: mRNA Synonyms: COX1|COX3|PCOX1|PES-1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 122370530 End Site(bp): 122395703 Gene Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000095303 HGNC ID: HGNC:9604 Entrez Gene: 5742

Expression Profile of PTGS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-22-3p YES YES YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-873-5p YES YES NO Display: