ctcRbase

Entry Detail

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General Information

Database ID: BRCA15087 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: XIAP Full Name: X-linked inhibitor of apoptosis Category: mRNA Synonyms: API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 Chromosome: chrX Strand: + Coordinate: Start Site(bp): 123859724 End Site(bp): 123913979 Gene Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000101966 HGNC ID: HGNC:592 Entrez Gene: 331

Expression Profile of XIAP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-122-5p YES NO YES hsa-miR-1271-5p YES NO YES hsa-miR-136-5p YES NO YES hsa-miR-142-3p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-149-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-17-5p YES NO YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-186-5p YES YES YES hsa-miR-192-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-214-3p YES YES NO hsa-miR-215-5p YES YES YES hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES NO YES hsa-miR-219a-5p YES YES NO hsa-miR-23a-3p YES NO YES hsa-miR-23b-3p YES NO YES hsa-miR-24-3p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-300 YES YES NO hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-330-3p YES NO YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-371a-5p YES NO YES hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-429 YES YES YES hsa-miR-431-5p YES YES YES hsa-miR-448 YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-494-3p YES NO YES hsa-miR-495-3p YES NO YES hsa-miR-519d-3p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-668-3p YES NO YES hsa-miR-7-5p YES NO YES hsa-miR-874-3p YES NO YES hsa-miR-93-5p YES NO YES hsa-miR-96-5p YES NO YES Display: