ctcRbase

Entry Detail

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General Information

Database ID: BRCA15278 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: GRK2 Full Name: G protein-coupled receptor kinase 2 Category: mRNA Synonyms: ADRBK1|BARK1|BETA-ARK1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 67266410 End Site(bp): 67286556 Gene Summary: This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] External Links: Ensembl ID: ENSG00000173020 HGNC ID: HGNC:289 Entrez Gene: 156

Expression Profile of GRK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-127-3p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-411-5p YES YES NO Display: