ctcRbase

Entry Detail

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General Information

Database ID: BRCA15329 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MXI1 Full Name: MAX interactor 1, dimerization protein Category: mRNA Synonyms: MAD2|MXD2|MXI|bHLHc11 Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 110207605 End Site(bp): 110287365 Gene Summary: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000119950 HGNC ID: HGNC:7534 Entrez Gene: 4601

Expression Profile of MXI1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-128-3p YES NO YES hsa-miR-129-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-132-3p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-17-5p YES NO YES hsa-miR-183-5p YES YES NO hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES YES hsa-miR-219a-2-3p YES NO YES hsa-miR-24-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-300 YES NO YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-328-3p YES NO YES hsa-miR-340-5p YES YES YES hsa-miR-361-5p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-375 YES NO YES hsa-miR-381-3p YES NO YES hsa-miR-421 YES YES YES hsa-miR-433-3p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-519d-3p YES NO YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-543 YES NO YES hsa-miR-874-3p YES YES YES hsa-miR-93-5p YES NO YES Display: