| ncRNA Symbol: | APH1B |
| Full Name: | aph-1 homolog B, gamma-secretase subunit |
| Category: | mRNA |
| Synonyms: | APH-1B|PRO1328|PSFL|TAAV688 |
| Chromosome: | chr15 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 63276018 | End Site(bp): | 63309126 |
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| Gene Summary: | This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011] |
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