ctcRbase

Entry Detail

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General Information

Database ID: BRCA15561 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: FBXW7 Full Name: F-box and WD repeat domain containing 7 Category: mRNA Synonyms: AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 Chromosome: chr4 Strand: - Coordinate: Start Site(bp): 152321259 End Site(bp): 152536101 Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000109670 HGNC ID: HGNC:16712 Entrez Gene: 55294

Expression Profile of FBXW7 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-137 YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-140-3p YES NO YES hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-188-5p YES NO YES hsa-miR-194-5p YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-206 YES YES YES hsa-miR-208b-3p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-219a-5p YES YES YES hsa-miR-223-3p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-338-3p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES YES hsa-miR-433-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-489-3p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-499a-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-599 YES YES NO hsa-miR-613 YES YES YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: