ctcRbase

Entry Detail

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General Information

Database ID: BRCA16102 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: MET Full Name: MET proto-oncogene, receptor tyrosine kinase Category: mRNA Synonyms: AUTS9|DFNB97|HGFR|RCCP2|c-Met Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 116672390 End Site(bp): 116798386 Gene Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] External Links: Ensembl ID: ENSG00000105976 HGNC ID: HGNC:7029 Entrez Gene: 4233

Expression Profile of MET Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-122-5p YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-361-5p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-599 YES YES NO hsa-miR-613 YES YES YES hsa-miR-876-5p YES YES NO hsa-miR-9-5p NO YES YES Display: