ctcRbase

Entry Detail

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General Information

Database ID: BRCA16362 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: DMTF1 Full Name: cyclin D binding myb like transcription factor 1 Category: mRNA Synonyms: DMP1|DMTF|MRUL|hDMP1 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 87152361 End Site(bp): 87196337 Gene Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] External Links: Ensembl ID: ENSG00000135164 HGNC ID: HGNC:14603 Entrez Gene: 9988

Expression Profile of DMTF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-142-3p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-147a YES NO NO hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-503-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-98-5p YES YES NO Display: