ctcRbase

Entry Detail

---



General Information

Database ID: BRCA16731 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PIM1 Full Name: Pim-1 proto-oncogene, serine/threonine kinase Category: mRNA Synonyms: PIM Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 37170203 End Site(bp): 37175426 Gene Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000137193 HGNC ID: HGNC:8986 Entrez Gene: 5292

Expression Profile of PIM1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-214-3p YES YES NO hsa-miR-24-3p YES YES YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-328-3p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-33a-5p YES NO YES hsa-miR-33b-5p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-431-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-486-5p YES YES YES hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-7-5p YES YES YES Display: