ctcRbase

Entry Detail

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General Information

Database ID: BRCA16763 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: STK4 Full Name: serine/threonine kinase 4 Category: mRNA Synonyms: KRS2|MST1|YSK3 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 44966474 End Site(bp): 45079959 Gene Summary: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000101109 HGNC ID: HGNC:11408 Entrez Gene: 6789

Expression Profile of STK4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-124-3p YES YES YES hsa-miR-129-2-3p YES NO YES hsa-miR-1297 YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-134-5p YES NO YES hsa-miR-139-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES NO YES hsa-miR-18b-5p YES NO YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-28-5p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-369-3p YES NO NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-448 YES YES YES hsa-miR-450a-5p YES YES NO hsa-miR-451a YES YES NO hsa-miR-486-5p YES YES YES hsa-miR-488-3p YES NO YES hsa-miR-491-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-708-5p YES YES YES hsa-miR-758-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-9-5p YES YES NO Display: