| ncRNA Symbol: | GRIA4 |
| Full Name: | glutamate ionotropic receptor AMPA type subunit 4 |
| Category: | mRNA |
| Synonyms: | GLUR4|GLUR4C|GLURD|GluA4|NEDSGA |
| Chromosome: | chr11 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 105609994 | End Site(bp): | 105982092 |
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| Gene Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] |
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