ctcRbase

Entry Detail

---



General Information

Database ID: BRCA17079 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PTPN12 Full Name: protein tyrosine phosphatase, non-receptor type 12 Category: mRNA Synonyms: PTP-PEST|PTPG1 Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 77537275 End Site(bp): 77640071 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000127947 HGNC ID: HGNC:9645 Entrez Gene: 5782

Expression Profile of PTPN12 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-145-5p YES NO YES hsa-miR-149-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-195-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-216a-5p YES NO YES hsa-miR-216b-5p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-338-3p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-490-3p YES YES YES hsa-miR-494-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-874-3p YES YES YES hsa-miR-875-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: