ctcRbase

Entry Detail

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General Information

Database ID: BRCA17644 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: KLHL12 Full Name: kelch like family member 12 Category: mRNA Synonyms: C3IP1|DKIR Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 202891100 End Site(bp): 202928636 Gene Summary: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000117153 HGNC ID: HGNC:19360 Entrez Gene: 59349

Expression Profile of KLHL12 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-338-3p NO YES YES hsa-miR-425-5p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES NO Display: