ctcRbase

Entry Detail

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General Information

Database ID: BRCA18003 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: SOCS3 Full Name: suppressor of cytokine signaling 3 Category: mRNA Synonyms: ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 78356778 End Site(bp): 78360077 Gene Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000184557 HGNC ID: HGNC:19391 Entrez Gene: 9021

Expression Profile of SOCS3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-134-5p YES YES NO hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-216b-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-379-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-455-5p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-551a YES YES NO hsa-miR-551b-3p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-874-3p YES YES NO Display: