ctcRbase

Entry Detail

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General Information

Database ID: BRCA18138 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: XRN1 Full Name: 5'-3' exoribonuclease 1 Category: mRNA Synonyms: SEP1 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 142306607 End Site(bp): 142448062 Gene Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] External Links: Ensembl ID: ENSG00000114127 HGNC ID: HGNC:30654 Entrez Gene: 54464

Expression Profile of XRN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-137 YES YES YES hsa-miR-138-5p YES NO YES hsa-miR-155-5p YES YES YES hsa-miR-17-5p YES NO YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-205-5p YES NO YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-211-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-32-5p YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-338-3p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-362-3p YES NO NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-370-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-409-3p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES YES hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES NO YES hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-93-5p YES NO YES hsa-miR-9-5p YES YES YES hsa-miR-98-5p YES NO YES Display: