ctcRbase

Entry Detail

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General Information

Database ID: BRCA18916 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MPZL2 Full Name: myelin protein zero like 2 Category: mRNA Synonyms: DFNB111|EVA|EVA1 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 118253403 End Site(bp): 118264536 Gene Summary: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000149573 HGNC ID: HGNC:3496 Entrez Gene: 10205

Expression Profile of MPZL2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-141-3p YES YES NO hsa-miR-142-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: