| ncRNA Symbol: | GFRA1 |
| Full Name: | GDNF family receptor alpha 1 |
| Category: | mRNA |
| Synonyms: | GDNFR|GDNFRA|GFR-ALPHA-1|RET1L|RETL1|TRNR1 |
| Chromosome: | chr10 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 116056925 | End Site(bp): | 116273467 |
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| Gene Summary: | This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] |
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