ctcRbase

Entry Detail

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General Information

Database ID: BRCA19662 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: KDM6B Full Name: lysine demethylase 6B Category: mRNA Synonyms: JMJD3 Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 7839904 End Site(bp): 7854796 Gene Summary: The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017] External Links: Ensembl ID: ENSG00000132510 HGNC ID: HGNC:29012 Entrez Gene: 23135

Expression Profile of KDM6B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES NO YES hsa-miR-101-3p YES YES YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-138-5p YES NO YES hsa-miR-139-5p YES YES YES hsa-miR-144-3p YES NO YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES NO YES hsa-miR-22-3p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-342-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-599 YES YES NO hsa-miR-7-5p YES NO YES hsa-miR-93-5p YES YES YES hsa-miR-99a-5p YES NO YES hsa-miR-99b-5p YES NO YES Display: