ctcRbase

Entry Detail

---



General Information

Database ID: BRCA20493 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PATZ1 Full Name: POZ/BTB and AT hook containing zinc finger 1 Category: mRNA Synonyms: MAZR|PATZ|RIAZ|ZBTB19|ZNF278|ZSG|dJ400N23 Chromosome: chr22 Strand: - Coordinate: Start Site(bp): 31325804 End Site(bp): 31346232 Gene Summary: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000100105 HGNC ID: HGNC:13071 Entrez Gene: 23598

Expression Profile of PATZ1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-134-5p YES YES YES hsa-miR-136-5p YES YES NO hsa-miR-142-3p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-216b-5p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-369-3p YES NO NO hsa-miR-375 YES NO YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-383-5p YES YES YES hsa-miR-421 YES YES NO hsa-miR-429 YES YES NO hsa-miR-448 YES YES NO hsa-miR-483-3p YES NO YES hsa-miR-490-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-96-5p YES YES NO Display: