ctcRbase

Entry Detail

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General Information

Database ID: BRCA20770 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: LMTK2 Full Name: lemur tyrosine kinase 2 Category: mRNA Synonyms: AATYK2|BREK|KPI-2|KPI2|LMR2|PPP1R100|cprk|hBREK Chromosome: chr7 Strand: + Coordinate: Start Site(bp): 98106885 End Site(bp): 98209633 Gene Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] External Links: Ensembl ID: ENSG00000164715 HGNC ID: HGNC:17880 Entrez Gene: 22853

Expression Profile of LMTK2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-135a-5p YES NO YES hsa-miR-135b-5p YES NO YES hsa-miR-140-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-152-3p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-192-5p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-215-5p YES NO YES hsa-miR-216a-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-24-3p YES NO YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-384 YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-486-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES YES Display: