ctcRbase

Entry Detail

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General Information

Database ID: BRCA20878 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CENPB Full Name: centromere protein B Category: mRNA Synonyms: - Chromosome: chr20 Strand: - Coordinate: Start Site(bp): 3783851 End Site(bp): 3786690 Gene Summary: This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000125817 HGNC ID: HGNC:1852 Entrez Gene: 1059

Expression Profile of CENPB Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-2-3p YES NO YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-485-5p YES YES NO Display: