ctcRbase

Entry Detail

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General Information

Database ID: BRCA20985 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: IREB2 Full Name: iron responsive element binding protein 2 Category: mRNA Synonyms: ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 78437431 End Site(bp): 78501456 Gene Summary: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000136381 HGNC ID: HGNC:6115 Entrez Gene: 3658

Expression Profile of IREB2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES NO hsa-miR-124-3p NO YES NO hsa-miR-1323 YES NO NO hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES NO YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-381-3p YES NO YES hsa-miR-421 YES NO YES hsa-miR-429 YES YES NO hsa-miR-448 YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-506-3p NO YES NO hsa-miR-543 YES YES YES hsa-miR-548o-3p YES NO NO hsa-miR-655-3p YES NO YES hsa-miR-9-5p YES YES NO hsa-miR-99a-5p YES YES NO hsa-miR-99b-5p YES YES NO Display: