ctcRbase

Entry Detail

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General Information

Database ID: BRCA22395 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: PPL Full Name: periplakin Category: mRNA Synonyms: - Chromosome: chr16 Strand: - Coordinate: Start Site(bp): 4882507 End Site(bp): 4960741 Gene Summary: The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000118898 HGNC ID: HGNC:9273 Entrez Gene: 5493

Expression Profile of PPL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-599 YES YES NO hsa-miR-875-5p YES YES NO Display: