ctcRbase

Entry Detail

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General Information

Database ID: BRCA24281 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: E2F1 Full Name: E2F transcription factor 1 Category: mRNA Synonyms: E2F-1|RBAP1|RBBP3|RBP3 Chromosome: chr20 Strand: - Coordinate: Start Site(bp): 33675683 End Site(bp): 33686404 Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000101412 HGNC ID: HGNC:3113 Entrez Gene: 1869

Expression Profile of E2F1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1298-5p YES NO YES hsa-miR-136-5p YES YES YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-205-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-329-3p YES YES YES hsa-miR-330-3p YES NO YES hsa-miR-342-3p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-493-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-93-5p YES YES YES Display: