ctcRbase

Entry Detail

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General Information

Database ID: BRCA27349 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: STRADA Full Name: STE20 related adaptor alpha Category: mRNA Synonyms: LYK5|NY-BR-96|PMSE|STRAD|STRAD alpha|Stlk Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 63682336 End Site(bp): 63741986 Gene Summary: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] External Links: Ensembl ID: ENSG00000266173 HGNC ID: HGNC:30172 Entrez Gene: 92335

Expression Profile of STRADA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-140-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-326 YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-542-3p YES YES NO hsa-miR-599 YES YES NO hsa-miR-642a-5p YES NO NO Display: