ctcRbase

Entry Detail

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General Information

Database ID: PAAD04292 Cancer Type: pancreatic cancer Dataset: GSE60407 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: G6PC Full Name: glucose-6-phosphatase catalytic subunit Category: mRNA Synonyms: G6PC1|G6PT|G6Pase|GSD1|GSD1a Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 42900797 End Site(bp): 42913369 Gene Summary: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011] External Links: Ensembl ID: ENSG00000131482 HGNC ID: HGNC:4056 Entrez Gene: 2538

Expression Profile of G6PC Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES NO YES hsa-miR-1297 YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-15a-5p NO YES YES hsa-miR-15b-5p NO YES YES hsa-miR-16-5p NO YES YES hsa-miR-183-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-195-5p NO YES YES hsa-miR-200a-3p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-424-5p NO YES YES hsa-miR-454-3p YES YES NO hsa-miR-485-5p NO YES YES hsa-miR-497-5p NO YES YES Display: