ctcRbase

Entry Detail

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General Information

Database ID: PRAD02828 Cancer Type: prostate cancer Dataset: GSE104209 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: FURIN Full Name: furin, paired basic amino acid cleaving enzyme Category: mRNA Synonyms: FUR|PACE|PCSK3|SPC1 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 90868592 End Site(bp): 90883458 Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] External Links: Ensembl ID: ENSG00000140564 HGNC ID: HGNC:8568 Entrez Gene: 5045

Expression Profile of FURIN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO YES hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-107 YES NO YES hsa-miR-124-3p YES YES YES hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-128-3p YES NO YES hsa-miR-129-2-3p YES NO YES hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-137 YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-215-5p YES YES NO hsa-miR-219a-5p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-448 YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-9-5p YES YES YES Display: