ctcRbase

Entry Detail

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General Information

Database ID: PRAD06006 Cancer Type: prostate cancer Dataset: GSE67980 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: KPNA6 Full Name: karyopherin subunit alpha 6 Category: mRNA Synonyms: IPOA7|KPNA7 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 32108038 End Site(bp): 32176568 Gene Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000025800 HGNC ID: HGNC:6399 Entrez Gene: 23633

Expression Profile of KPNA6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES NO YES hsa-miR-125b-5p YES NO YES hsa-miR-128-3p YES NO YES hsa-miR-129-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-1321 YES NO NO hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-144-3p YES NO YES hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-15a-5p YES NO NO hsa-miR-15b-5p YES NO NO hsa-miR-16-5p YES NO NO hsa-miR-186-5p YES NO YES hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-192-5p YES YES YES hsa-miR-195-5p YES NO NO hsa-miR-197-3p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-215-5p YES YES YES hsa-miR-224-5p YES NO YES hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-300 YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-331-3p YES NO YES hsa-miR-335-5p YES NO YES hsa-miR-342-3p YES YES YES hsa-miR-378a-3p YES YES YES hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES NO YES hsa-miR-422a YES YES YES hsa-miR-424-5p YES NO NO hsa-miR-425-5p YES NO YES hsa-miR-489-3p YES NO YES hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES NO NO hsa-miR-532-3p YES NO YES hsa-miR-582-5p YES NO YES hsa-miR-625-5p YES NO NO hsa-miR-655-3p YES NO YES hsa-miR-873-5p YES NO YES hsa-miR-876-5p YES NO YES Display: